Versatile click alginate hydrogels crosslinked via tetrazine–norbornene chemistry
نویسندگان
چکیده
منابع مشابه
Versatile click alginate hydrogels crosslinked via tetrazine-norbornene chemistry.
Alginate hydrogels are well-characterized, biologically inert materials that are used in many biomedical applications for the delivery of drugs, proteins, and cells. Unfortunately, canonical covalently crosslinked alginate hydrogels are formed using chemical strategies that can be biologically harmful due to their lack of chemoselectivity. In this work we introduce tetrazine and norbornene grou...
متن کاملClick-Crosslinked Injectable Gelatin Hydrogels.
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and ...
متن کاملA versatile new monomer family: functionalized 4-vinyl-1,2,3-triazoles via click chemistry.
Using facile, highly modular synthetic approaches, a new monomer family based on a 1,2,3-triazole-4-vinyl building block has been prepared, and various functional derivatives have been obtained. Subsequent homo- and copolymerization of these novel functionalized monomers gives polymeric materials with unique physical properties, combining many attractive features of more traditional monomers, s...
متن کاملA new class of dual responsive self-healable hydrogels based on a core crosslinked ionic block copolymer micelle prepared via RAFT polymerization and Diels-Alder "click" chemistry.
Amphiphilic diblock copolymers of poly(furfuryl methacrylate) (PFMA) with cationic poly(2-(methacryloyloxy)ethyltrimethyl ammonium chloride) (PFMA-b-PMTAC) and anionic poly(sodium 4-vinylbenzenesulfonate) (PFMA-b-PSS) were prepared via reversible addition fragmentation chain-transfer (RAFT) polymerization by using PFMA as a macro-RAFT agent. The formation of the block copolymer was confirmed by...
متن کاملA versatile "click" chemistry precursor of functional polystyrene nanoparticles.
Functional nanoparticles (NPs) are becoming important building blocks in the emerging fi elds of nanomedicine, nanolithography and nanoelectronics, among others. [ 1 ] Several unexpected nanoscale effects have been discovered for these new materials in recent years. [ 2–4 ] Useful synthetic routes to single-molecule polymeric NPs in the 2–15 nm size range with well-defi ned arrangement of funct...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomaterials
سال: 2015
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2015.01.048